The metabolic comparison of HPD in normal brain tissue and S180 sarcoma in brain

Yu Wang; Jing Zhu; Huiguo Zhang

doi:10.1117/12.639298

11 September 2006 The metabolic comparison of HPD in normal brain tissue and S180 sarcoma in brain

Yu Wang, Jing Zhu, Huiguo Zhang

Proceedings Volume 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery; 596713 (2006) https://doi.org/10.1117/12.639298
Event: 2004 Shanghai international Conference on Laser Medicine and Surgery, 2004, Shanghai, China

Abstract

Objective: Search The Metabolic Comparision of HPD in Normal Brain Tissue and S180 sarcoma in brain. Methods: Xe laser photoradiation of normal brain tissue and S180 sarcoma in brain to excite fluorescence was performed at different time after the injection of hematoporphyrin derivative (HpD) in normal rats and rats with S180 sarcoma of Brain. We analysed HPD fluorescence lifetime imaging (wavelength: 630 nm and 690 nm) of two rat team with OMA. Result: We concluded the peak intensity of HPD fluorescence fell obviously in normal brain three hours later after injection, while it still retained high HPD concentration in sarcoma of Brain. Conclusion: first-rank time the 4~5 hours after injection of HPD is first-rank time 0f PDT and photosensitive diagnose in sarcoma of Brain of rat.

Citation Download Citation

Yu Wang, Jing Zhu, and Huiguo Zhang "The metabolic comparison of HPD in normal brain tissue and S180 sarcoma in brain", Proc. SPIE 5967, 2004 Shanghai International Conference on Laser Medicine and Surgery, 596713 (11 September 2006); https://doi.org/10.1117/12.639298

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