Noninvasive optical monitoring of rat brain and effects of the injection of tracers for blood flow measurements

Raphael Sablong; E. Grillon; Oliver Hugon; Jacques Derouard

doi:10.1117/12.447142

31 October 2001 Noninvasive optical monitoring of rat brain and effects of the injection of tracers for blood flow measurements

Raphael Sablong, E. Grillon, Oliver Hugon, Jacques Derouard

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Proceedings Volume 4432, Diagnostic Optical Spectroscopy in Biomedicine; (2001) https://doi.org/10.1117/12.447142
Event: European Conferences on Biomedical Optics, 2001, Munich, Germany

Abstract

Near infrared spectroscopy using either broad band reflectance spectrophotometry or monochromatic illumination has been carried out to monitor non invasively the changes of the concentrations of chromophores in rat brain induced by the intravenous injection of various contrast agents (indocyanine green, ultrasmall magnetic particles suspension, albumine, dextran, or saline solution alone). Depending of the wavelength and of the absorption spectrum of the injected compound the bolus can be seen either by a decrease or an increase of the transmitted light, this latter due to the induced dilution of the blood by the bolus. We suggest that this could be used to determine the arterial input function of the contrast agent needed to perform absolute cerebral blood flow imaging by nuclear magnetic resonance.

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Raphael Sablong, E. Grillon, Oliver Hugon, and Jacques Derouard "Noninvasive optical monitoring of rat brain and effects of the injection of tracers for blood flow measurements", Proc. SPIE 4432, Diagnostic Optical Spectroscopy in Biomedicine, (31 October 2001); https://doi.org/10.1117/12.447142

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KEYWORDS

Brain

Magnetism

Heart

Near infrared spectroscopy

Electrocardiography

Absorption

Data acquisition

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