Spatial sensitivity profiles by time-resolved fluorescence Monte Carlo simulation

Praveen Kadimcherla; Mostafa Sadoqi; Sunil Kumar

doi:10.1117/12.478179

29 July 2003 Spatial sensitivity profiles by time-resolved fluorescence Monte Carlo simulation

Praveen Kadimcherla, Mostafa Sadoqi, Sunil Kumar

Proceedings Volume 4955, Optical Tomography and Spectroscopy of Tissue V; (2003) https://doi.org/10.1117/12.478179
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

Many investigations in the literature have studied the migration of photons in fluorescent and non-fluorescent applications, both in the steady-state and time-resolved, within a tissue-simulating medium. However, none have addressed the specific issue of quantified the subsequent migration path of the emitted photons. This is important since fluorescent spectroscopy has been gaining acceptance as an important diagnostic tool. In this paper we show the migration patterns of fluorescent photons with respect to time in a scattering medium such as tissue. The images produced are of the paths of the emission photons that reach the detector. We are able to observe how they migrate at different times. We investigate the effect of the absorption and scattering coefficients on the migration patterns, and how it could give us information about methods to detect inhomogeneities in the medium. The images produced give us information about the accuracy of the estimation of the optical properties in particular medium. Finally, we study how the detector position and absorption and scattering coefficients affect the source of the photons that reach the detector. We discover that during the rising time of the temporal spectrum most of the detected fluorescent photons are being generated very close to the source and the path followed by these photons are localized near the detector. Therefore, we could explore this for the best orientation and location of the detector and source positions to locate inhomogenieties and also source of fluorescence photons within the medium.

Citation Download Citation

Praveen Kadimcherla, Mostafa Sadoqi, and Sunil Kumar "Spatial sensitivity profiles by time-resolved fluorescence Monte Carlo simulation", Proc. SPIE 4955, Optical Tomography and Spectroscopy of Tissue V, (29 July 2003); https://doi.org/10.1117/12.478179

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KEYWORDS

Photons

Sensors

Scattering

Monte Carlo methods

Tissue optics

Absorption

Luminescence

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