OCT imaging of the larynx: a feasibility study

Athanasios G. Bibas M.D.; Adrian Gh. Podoleanu; Radu G. Cucu; Mathias Bonmarin; George M. Dobre; Vicky Ward; Edward O'Dell; Aaron Boxer; Michael J. Gleeson; David A. Jackson

doi:10.1117/12.477886

8 July 2003 OCT imaging of the larynx: a feasibility study

Athanasios G. Bibas M.D., Adrian Gh. Podoleanu, Radu G. Cucu, Mathias Bonmarin, George M. Dobre, Vicky Ward, Edward O'Dell, Aaron Boxer, Michael J. Gleeson, David A. Jackson

Author Affiliations +

Proceedings Volume 4956, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII; (2003) https://doi.org/10.1117/12.477886
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

Laryngeal cancer is the most common primary head and neck malignancy and the need for early identification is very important for early treatment. Outpatient fiberoptic examination of the larynx is often unreliable in differentiating between benign, pre-malignant and malignant lesions, and therefore surgeons often have to rely on biopsies for a definite diagnosis. This is an invasive procedure requiring general anaesthesia and may have a detrimental effect on patient’s voice. The aim of our study was to investigate the feasibility of optical coherence tomography in imaging of the larynx, which will lay the foundations for investigating its ability to differentiate between benign and malignant disease. Tissue specimens from normal larynges were imaged with a polarisation sensitive OCT system at 850 nm and a second OCT system at 1300 nm. Both OCT systems were capable of providing both B-scan (longitudinal OCT) images as well as C-scan (en-face OCT or at constant depth) images. Imaged specimens were processed with standard histopathological techniques and sectioned in the plane of the B-scan OCT images. Haematoxylin-Eosin stained specimens were compared to the OCT images. Preliminary results showed good correlation between OCT images and histology sections in normal tissues.

Citation Download Citation

Athanasios G. Bibas M.D., Adrian Gh. Podoleanu, Radu G. Cucu, Mathias Bonmarin, George M. Dobre, Vicky Ward, Edward O'Dell, Aaron Boxer, Michael J. Gleeson, and David A. Jackson "OCT imaging of the larynx: a feasibility study", Proc. SPIE 4956, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VII, (8 July 2003); https://doi.org/10.1117/12.477886

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available