High-resolution in-vivo micro-CT scanner for small animals

Alexander Sasov; Daniel Dewaele

doi:10.1117/12.452844

7 January 2002 High-resolution in-vivo micro-CT scanner for small animals

Alexander Sasov, Daniel Dewaele

Proceedings Volume 4503, Developments in X-Ray Tomography III; (2002) https://doi.org/10.1117/12.452844
Event: International Symposium on Optical Science and Technology, 2001, San Diego, CA, United States

Abstract

Small laboratory animals (mice and rats) are widely used in development of drugs and treatments. To recognize the internal changes in the very early stage inside the body of alive animal, high-resolution micro-CT scanner has been developed. Initial changes in the bone structure can be found as features in the size range of 10 microns. By this reason a voxel size for reconstructed cross sections has been chosen as small as 10 microns. Full animal body may be up to 80 mm in diameter and up to 200 mm in length. By this reason the reconstructed cross section format selected as 8000 x 8000 pixels (float-point). A new 2D detection system with multibeam geometry produces dataset for reconstruction of hundreds of cross sections after one scan. Object illuminated by microfocus sealed x-ray source with 5 microns spot size. Continuously variable energy in the range of 20- 100 kV and energy filters allows estimate material composition like in DEXA systems. Direct streaming of the projection data to the disk reduce irradiation dose to the animal under scanning. Software package can create realistic 3D images from the set of reconstructed cross sections and calculate internal morphological parameters.

Citation Download Citation

Alexander Sasov and Daniel Dewaele "High-resolution in-vivo micro-CT scanner for small animals", Proc. SPIE 4503, Developments in X-Ray Tomography III, (7 January 2002); https://doi.org/10.1117/12.452844

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