Comparison of in-vivo optical imaging of brain functional activity: intrinsic signal imaging and laser speckle imaging

Zheng Wang; Qingming Luo; Haiying Cheng

doi:10.1117/12.462531

12 April 2002 Comparison of in-vivo optical imaging of brain functional activity: intrinsic signal imaging and laser speckle imaging

Zheng Wang, Qingming Luo, Haiying Cheng

Author Affiliations +

Proceedings Volume 4536, International Workshop on Photonics and Imaging in Biology and Medicine; (2002) https://doi.org/10.1117/12.462531
Event: International Workshop on Photonics and Imaging in Biology and Medicine, 2001, Wuhan, China

Abstract

At present, the easiest and most effective strategy of imaging functional architecture is based on the slow intrinsic changes in the optical properties of active brain tissue, permitting visualization of active cortical regions at a spatial resolution better than 50 micrometers . This can be accomplished without some of the problems associated with the use of extrinsic probes. Monitoring the spatio-temporal characteristics of cerebral blood flow (CBF) is crucial for studying the normal and pathological conditions of brain metabolism. Laser dynamic speckle imaging technique achieves this goal without the need for scanning by utilizing the spatial statistics of time-integrated speckle, which was first proposed by Fercher and Briers in the early eighties. Considering similarity of these two experimental systems, we are trying to integrate them into one system in order to acquire much more neurophysiological information simultaneously.

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Zheng Wang, Qingming Luo, and Haiying Cheng "Comparison of in-vivo optical imaging of brain functional activity: intrinsic signal imaging and laser speckle imaging", Proc. SPIE 4536, International Workshop on Photonics and Imaging in Biology and Medicine, (12 April 2002); https://doi.org/10.1117/12.462531

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KEYWORDS

Brain

Blood circulation

Neuroimaging

Optical imaging

Spatial resolution

Speckle

Blood

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