Estimation of glucose diffusion coefficient in scleral tissue

Alexey N. Bashkatov; Elina A. Genina; Yurii P. Sinichkin; Nina A. Lakodina; Vyacheslav I. Kochubey; Valery V. Tuchin

doi:10.1117/12.381513

6 April 2000 Estimation of glucose diffusion coefficient in scleral tissue

Alexey N. Bashkatov, Elina A. Genina, Yurii P. Sinichkin, Nina A. Lakodina, Vyacheslav I. Kochubey, Valery V. Tuchin

Proceedings Volume 4001, Saratov Fall Meeting '99: Optical Technologies in Biophysics and Medicine; (2000) https://doi.org/10.1117/12.381513
Event: Saratov Fall Meeting '99, 1999, Saratov, Russian Federation

Abstract

Results of experimental and theoretical study of the optical properties of the eye sclera controlled by administration of osmotically active chemical, such as glucose, are presented. Glucose administration induces the diffusion of matter and as a result the equalization of the refractive indices of collagen fibrils and base material, and corresponding changes of transmittance spectra of scleral tissue. Transmittance spectra of the human scleral samples impregnated by glucose were measured. The significant increase of transmittance under action of osmotic liquid was observed. The diffusion coefficient of glucose within scleral tissue was estimated; the average value is 3.45 X 10^-6 +/- 4.59 X 10^-7 cm²/sec. The results are general and can be used to describe many other fibrous tissues impregnated by osmotically active chemical agents.

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Alexey N. Bashkatov, Elina A. Genina, Yurii P. Sinichkin, Nina A. Lakodina, Vyacheslav I. Kochubey, and Valery V. Tuchin "Estimation of glucose diffusion coefficient in scleral tissue", Proc. SPIE 4001, Saratov Fall Meeting '99: Optical Technologies in Biophysics and Medicine, (6 April 2000); https://doi.org/10.1117/12.381513

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