In-vivo tissue repair using light-activated surgical adhesive in a porcine model

Karen M. McNally-Heintzelman; Jill N. Riley; Tonya J. Dickson; Dong Ming Hou; Pamela Rogers; Keith L. March

doi:10.1117/12.427796

21 May 2001 In-vivo tissue repair using light-activated surgical adhesive in a porcine model

Karen M. McNally-Heintzelman, Jill N. Riley, Tonya J. Dickson, Dong Ming Hou, Pamela Rogers, Keith L. March

Proceedings Volume 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI; (2001) https://doi.org/10.1117/12.427796
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

An in vivo study was conducted to investigate the feasibility, mechanical function, and chronic biocompatibility of a new light-activated surgical adhesive for achieving rapid hemostasis of the puncture site following diagnostic catheterization and interventional cardiac procedures. Porcine carotid arteries (nequals6) and femoral arteries (nequals6) were exposed, and an incision was made in the arterial walls using a 16G needle. The surgical adhesive, composed of a poly(L-lactic-co-glycolic acid) scaffold doped with the traditional protein solder mix of serum albumin and indocyanine green dye, was used to close the incisions in conjunction with an 805-nm diode laser. Blood flow was restored to the vessels immediately after the procedure and the incision sites were checked for patency. The strength and hemostatic abilities of the new surgical adhesive were evaluated in the context of arterial pressure, persistence of hemostatis and presence of any inflammatory reaction after 3 days. After this evaluation period, the surgical procedure was repeated on the carotid arteries (nequals6) and femoral arteries (nequals6) of three additional animals that had been heparinized prior to surgery to closer approximate the conditions seen in a typical vascular surgical setting.

Citation Download Citation

Karen M. McNally-Heintzelman, Jill N. Riley, Tonya J. Dickson, Dong Ming Hou, Pamela Rogers, and Keith L. March "In-vivo tissue repair using light-activated surgical adhesive in a porcine model", Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); https://doi.org/10.1117/12.427796

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