Multichannel optical mapping: investigation of depth information

Ichiro Sase; Hideo Eda; Akitoshi Seiyama; Hiroki C. Tanabe; Akira Takatsuki; Toshio Yanagida

doi:10.1117/12.434499

29 June 2001 Multichannel optical mapping: investigation of depth information

Ichiro Sase, Hideo Eda, Akitoshi Seiyama, Hiroki C. Tanabe, Akira Takatsuki, Toshio Yanagida

Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434499
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Near infrared (NIR) light has become a powerful tool for non-invasive imaging of human brain activity. Many systems have been developed to capture the changes in regional brain blood flow and hemoglobin oxygenation, which occur in the human cortex in response to neural activity. We have developed a multi-channel reflectance imaging system, which can be used as a `mapping device' and also as a `multi-channel spectrophotometer'. In the present study, we visualized changes in the hemodynamics of the human occipital region in multiple ways. (1) Stimulating left and right primary visual cortex independently by showing sector shaped checkerboards sequentially over the contralateral visual field, resulted in corresponding changes in the hemodynamics observed by `mapping' measurement. (2) Simultaneous measurement of functional-MRI and NIR (changes in total hemoglobin) during visual stimulation showed good spatial and temporal correlation with each other. (3) Placing multiple channels densely over the occipital region demonstrated spatial patterns more precisely, and depth information was also acquired by placing each pair of illumination and detection fibers at various distances. These results indicate that optical method can provide data for 3D analysis of human brain functions.

Citation Download Citation

Ichiro Sase, Hideo Eda, Akitoshi Seiyama, Hiroki C. Tanabe, Akira Takatsuki, and Toshio Yanagida "Multichannel optical mapping: investigation of depth information", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434499

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