Effect of multiple layers on diffuse optical tomography

Vasilis Ntziachristos; Jorge Ripoll; Joseph P. Culver; Arjun G. Yodh; Britton Chance; Manuel Nieto-Vesperinas

doi:10.1117/12.434478

29 June 2001 Effect of multiple layers on diffuse optical tomography

Vasilis Ntziachristos, Jorge Ripoll, Joseph P. Culver, Arjun G. Yodh, Britton Chance, Manuel Nieto-Vesperinas

Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434478
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

In this work we investigate the effect of a layer on Diffuse Optical Tomography of tissue. Such layers could be tissue structures (such as the skin or a fat-layer) or layers formed by compression plates. Our analysis uses an analytical forward model that is based on the angular spectrum representation of the propagating photon density wave in a diffuse medium. The inversion employs a standard perturbation expansion based on the Rytov approximation that is uses appropriate volume segmentation and solved using the algebraic reconstruction technique. The results demonstrate that the effect of biologically relevant multi-layer schemes can lead to significant reconstruction errors both in terms of quantification and positional certainty. The work is focussed on geometries and optical properties typical to the human breast, however the results are general and can apply to other tissue as well.

Citation Download Citation

Vasilis Ntziachristos, Jorge Ripoll, Joseph P. Culver, Arjun G. Yodh, Britton Chance, and Manuel Nieto-Vesperinas "Effect of multiple layers on diffuse optical tomography", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434478

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KEYWORDS

Diffuse optical tomography

Tissue optics

Tissues

Optical properties

Reconstruction algorithms

Mathematical modeling

Multilayers

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