Development and calibration of an automated Mueller matrix polarization system for skin lesion differentiation

Aimee R. Hill; B. D. Cameron; J. R. Chung; Justin S. Baba; Gerard L. Cote

doi:10.1117/12.434480

29 June 2001 Development and calibration of an automated Mueller matrix polarization system for skin lesion differentiation

Aimee R. Hill, B. D. Cameron, J. R. Chung, Justin S. Baba, Gerard L. Cote

Author Affiliations +

Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434480
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

In this paper, we describe the use of the full sixteen element Mueller matrix to differentiate between surface lesions on the skin, as an eventual noninvasive diagnostic technique for detection of certain types of skin cancers. A semi-automated system using a polarized light beam and a computer controlled CCD camera was developed to collect 16 polarization images of a sample and to calculate the complete Mueller matrix in near real time. The system was initially calibrated and the accuracy and precision were evaluated with a mirror and polarizer. This study also includes in vivo results from normal skin, a benign nevus, and a known cancerous lesion acquired from a single Sinclair swine. Differences were observed between the Mueller matrices of all three in vivo cases. These preliminary results demonstrate the potential for using an automated polarization imaging apparatus for eventual clinical cancer diagnostics.

Citation Download Citation

Aimee R. Hill, B. D. Cameron, J. R. Chung, Justin S. Baba, and Gerard L. Cote "Development and calibration of an automated Mueller matrix polarization system for skin lesion differentiation", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434480

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