Theoretical study of the detection of activated position in cerebral cortex from NIR signal

Yoshihiko Kashio; Eiji Okada

doi:10.1117/12.434483

29 June 2001 Theoretical study of the detection of activated position in cerebral cortex from NIR signal

Yoshihiko Kashio, Eiji Okada

Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434483
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Near infrared (NIR) spectroscopy and imaging have been applied to measure oxygenation change in the brain. Multi- channel NIR system can obtain topographic image of brain function. However poor spatial resolution due to tissue scattering is serious problem of NIR imaging. In this study, we propose a simple method to estimate the center of the absorption change in the brain from the signal detected with multi-channel NIR system. The theoretical analysis of photon measurement density functions for the adjoining source- detector pairs in multi-channel NIR system suggests that the difference in intensity between the adjoining source- detector pairs almost linearly relates with the position of the absorption perturbation. The proposed method to estimate the center of the absorption change in the brain is evaluated by using three layered head model. The estimated position is almost consistent with the center of the absorption change. In case where the broad absorption change occurred close to the edge of the measuring region, the estimated position tends to be shifted inward of the measuring region.

Citation Download Citation

Yoshihiko Kashio and Eiji Okada "Theoretical study of the detection of activated position in cerebral cortex from NIR signal", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434483

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