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Proceedings Article

Frequency-domain fluorescent diffusion tomography of turbid media and in-vivo tissues

[+] Author Affiliations
Ye Yang, Nicusor Iftimia, Yong Xu, Huabei Jiang

Clemson Univ. (USA)

Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, 537 (June 29, 2001); doi:10.1117/12.434529
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From Conference Volume 4250

  • Optical Tomography and Spectroscopy of Tissue IV
  • Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva M. Sevick-Muraca
  • San Jose, CA | January 20, 2001

abstract

The reconstruction of fluorescence lifetime distributions in heterogeneous turbid media and tumor-bearing animals are experimentally demonstrated by frequency-domain measurements. A set of coupled diffusion equations are used to describe the propagation of excitation and fluorescent emission light in multiply scattering media. A finite element based reconstruction algorithm combined with Marquardt and Tikhonov regularization methods are used to obtain the fluorescence images. The experimental set-up is an automatic multi-channel frequency-domain system. 16 sources and 16 detectors are used. Experiments are performed using indocyanine green (ICG) and 3,3'-diethylthiatricarbocyanine iodide (DTTCI) in tissue-like phantoms of both single- and multi-target configurations with considerations of perfect and imperfect uptake of fluorescence dyes in the scattering media. ICG are used in tumor-bearing animal studies. Our results show that the fluorescence lifetime image of the heterogeneities within a circular surrounding medium and in-vivo tissue can be reconstructed successfully.

© (2001) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Ye Yang ; Nicusor Iftimia ; Yong Xu and Huabei Jiang
"Frequency-domain fluorescent diffusion tomography of turbid media and in-vivo tissues", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, 537 (June 29, 2001); doi:10.1117/12.434529; http://dx.doi.org/10.1117/12.434529


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