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Proceedings Article

Interferometric phase-based dual-wavelength tomography

[+] Author Affiliations
Changhuei Yang, Adam Wax, Ramachandra R. Dasari, Michael S. Feld

Massachusetts Institute of Technology (USA)

Proc. SPIE 4251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V, 63 (May 23, 2001); doi:10.1117/12.427872
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From Conference Volume 4251

  • Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V
  • Valery V. Tuchin; Joseph A. Izatt; James G. Fujimoto
  • San Jose, CA, United States | January 20, 2001

abstract

We describe our phase-sensitive interferometry technique implemented as phase dispersion microscopy (PDM)/optical tomography (PDOT). The technique is based on measuring the phase difference between fundamental and second harmonic low coherence light in a novel interferometer. We attain high sensitivity to subtle refractive index differences due to dispersion with a differential optical path sensitivity of 5 nm. Using PDM, we show that ballistic light in a turbid medium undergoes a phase velocity change that is dependent on scatterer size. We demonstrate that the microscopy technique performs better than a conventional phase contrast microscope in imaging dispersive and weakly scattering samples. The tomographic implementation of the technique (PDOT) can complement Optical Coherence Tomography (OCT) by providing phase information about the scanned object.

© (2001) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Changhuei Yang ; Adam Wax ; Ramachandra R. Dasari and Michael S. Feld
"Interferometric phase-based dual-wavelength tomography", Proc. SPIE 4251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V, 63 (May 23, 2001); doi:10.1117/12.427872; http://dx.doi.org/10.1117/12.427872


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