Usefulness of indocyanine green as an infrared marker

Yuko Fukami; Manabu Heya; Kunio Awazu

doi:10.1117/12.432493

2 July 2001 Usefulness of indocyanine green as an infrared marker

Yuko Fukami, Manabu Heya, Kunio Awazu

Proceedings Volume 4259, Biomarkers and Biological Spectral Imaging; (2001) https://doi.org/10.1117/12.432493
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Indocyanide green (ICG) is widely used as a tracer for the non-invasive estimation of liver function. ICG has properties of binding with plasma protein, and has a large absorption peak at 805 nm. There were no reports, however, about the IR absorption peak of ICG at 7.1 micrometers , which absorption coefficient amounts to approximately 13000cm^-1. In this study, ICG was exposed to free electron lasers (FELs) with wavelength of 7.1 micrometers and usefulness of ICG as an IR-marker was discussed. ICG film sample was formed on IR-transparent BaF₂ crystal substrate and exposed to FELs with the wavelength of 7.1micrometers . After exposure the sample was analyzed by FT-IR and film thickness measurements. As results, ICG ablated with the FEL of the power density of more than 5 W/cm²(equalsP_dth), and that the molecular structure of ICG was still stable for the power density of less than P_dth, 3 W/cm². Therefore, ICG can be considered as a novel infrared marker (IR marker) to the living tissue which absorbs FEL photon energy without changing the IR absorption peak.

Citation Download Citation

Yuko Fukami, Manabu Heya, and Kunio Awazu "Usefulness of indocyanine green as an infrared marker", Proc. SPIE 4259, Biomarkers and Biological Spectral Imaging, (2 July 2001); https://doi.org/10.1117/12.432493

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