Diagnostic potential of erythrocytes aggregation and sedimentation measurements in whole blood samples

Juergen Lademann; Heike Richter; W. Sterry; Alexander V. Priezzhev

doi:10.1117/12.429328

13 June 2001 Diagnostic potential of erythrocytes aggregation and sedimentation measurements in whole blood samples

Juergen Lademann, Heike Richter, W. Sterry, Alexander V. Priezzhev

Proceedings Volume 4263, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring; (2001) https://doi.org/10.1117/12.429328
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

The membranes of the erythrocytes are covered with different kinds of proteins determining decisively the aggregation and disaggregation properties of erythrocytes. Morbid changes in the human body are reflected by changes in the kind and concentration of these proteins and this way by the aggregation and disaggregation behavior of erythrocytes. Light scattering measurements were used for the investigation of these changes comparing healthy volunteers and patients with different diseases. The whole blood samples were analyzed using a rotating coaxial cylinder system in combination with a special method for data processing. The erythrocyte aggregates were destroyed completely without injuring the cell membranes by shear forces arising during the cylinder rotation. In this paper the results of aggregation and disaggregation analysis of erythrocytes in whole blood samples of healthy volunteers and patients suffering different diseases are presented. The method of erythrocyte aggregation and disaggregation measurements is compared with blood sedimentation measurements.

Citation Download Citation

Juergen Lademann, Heike Richter, W. Sterry, and Alexander V. Priezzhev "Diagnostic potential of erythrocytes aggregation and sedimentation measurements in whole blood samples", Proc. SPIE 4263, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring, (13 June 2001); https://doi.org/10.1117/12.429328

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