Amplifying fluorescent polymer detection of bioanalytes

Lawrence F. Hancock; Robert Deans; Joongho Moon; Timothy M. Swager

doi:10.1117/12.456910

21 February 2002 Amplifying fluorescent polymer detection of bioanalytes

Lawrence F. Hancock, Robert Deans, Joongho Moon, Timothy M. Swager

Proceedings Volume 4575, Chemical and Biological Early Warning Monitoring for Water, Food, and Ground; (2002) https://doi.org/10.1117/12.456910
Event: Environmental and Industrial Sensing, 2001, Boston, MA, United States

Abstract

Nomadics and Professor Timothy Swager have collaborated extensively on the development of Amplifying Fluorescent Polymer (AFP) sensing technologies. AFPs are fully conjugated polymers which link many fluorphores into what is in effect, a molecular wire. Once linked, the ensemble of fluorophores will respond to a transduction event at any individual fluorophore. As a result, each individual analyte interaction will produce an effect in a much larger ensemble of fluorphores, amplifying each sensing event. Nomadics capitalized on this effect to construct a handheld landmine detector, which can identify buried landmines by sensing the trace signature of TNT vapor emanating from a mine. This presentation will describe efforts of Nomadics and the Swager group to leverage the intrinsic amplification of AFP systems for bioanalyte detection.

Citation Download Citation

Lawrence F. Hancock, Robert Deans, Joongho Moon, and Timothy M. Swager "Amplifying fluorescent polymer detection of bioanalytes", Proc. SPIE 4575, Chemical and Biological Early Warning Monitoring for Water, Food, and Ground, (21 February 2002); https://doi.org/10.1117/12.456910

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available