Light-induced fluorescence endoscopy (LIFE) imaging system for early cancer detection

Haishan Zeng; Calum E. MacAulay; Stephen Lam; Branko Palcic

doi:10.1117/12.364398

17 September 1999 Light-induced fluorescence endoscopy (LIFE) imaging system for early cancer detection

Haishan Zeng, Calum E. MacAulay, Stephen Lam, Branko Palcic

Proceedings Volume 3863, 1999 International Conference on Biomedical Optics; (1999) https://doi.org/10.1117/12.364398
Event: International Symposium on Biomedical Optics, 1999, Wuhan, China

Abstract

This paper summarizes our experiences on the development of a Light Induced Fluorescence Endoscopy (LIFE) imaging system for early cancer detection in the respiratory and gastrointestinal tract. The system utilizes tissue autofluorescence to provide real time video imaging of the examined organ. No exogenous fluorescent tumor markers are needed. It is used by a physician in adjunct to conventional white-light endoscopy. Suspicious areas are identified in pseudo color to guide biopsy. A multi- center clinical trial has demonstrated that in the lung, the relative sensitivity of white-light imaging + LIFE imaging vs. white-light imaging alone was 6.3 for intraepithelial neoplastic lesion detection and 2.71 when invasive carcinomas were also included. The following issues will be discussed: (1) spectroscopy study design for imaging system development; (2) architecture of the imaging systems; (3) different imaging modalities (white-light imaging, dual channel fluorescence imaging, and combined fluorescence/reflectance imaging); and (4) clinical applications.

Citation Download Citation

Haishan Zeng, Calum E. MacAulay, Stephen Lam, and Branko Palcic "Light-induced fluorescence endoscopy (LIFE) imaging system for early cancer detection", Proc. SPIE 3863, 1999 International Conference on Biomedical Optics, (17 September 1999); https://doi.org/10.1117/12.364398

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