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Proceedings Article

Detection of glutamate in the eye by Raman spectroscopy

[+] Author Affiliations
Alvin Katz, Glenn Minko, C. H. Liu, Robert R. Alfano

CUNY/City College (USA)

Erik F. Kruger, Richard B. Rosen

New York Eye and Ear Infirmary (USA)

Proc. SPIE 4098, Optical Devices and Diagnostics in Materials Science, 169 (September 29, 2000); doi:10.1117/12.401625
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From Conference Volume 4098

  • Optical Devices and Diagnostics in Materials Science
  • David L. Andrews; Toshimitsu Asakura; Suganda Jutamulia; Wiley P. Kirk; Max G. Lagally; Ravindra B. Lal; James D. Trolinger
  • San Diego, CA | July 30, 2000

abstract

In this work, Raman spectroscopy was investigated as a tool for monitoring glutamate levels in the eye. Glutamate is a by product of nerve cell death, and is an indicator of macular degeneration. Raman spectra was from ex vivo porcine eyes was investigated, with glutamate injected into the eyes to simulate disease conditions. The Raman spectra from the native eye was dominated by the lens. However, an optical system was designed to optimize collection of signal from the vitreous and reduce the background lens signal. The molecular signature of glutamate was detectable in the Raman spectra by this system.

© (2000) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Alvin Katz ; Erik F. Kruger ; Glenn Minko ; C. H. Liu ; Richard B. Rosen, et al.
"Detection of glutamate in the eye by Raman spectroscopy", Proc. SPIE 4098, Optical Devices and Diagnostics in Materials Science, 169 (September 29, 2000); doi:10.1117/12.401625; http://dx.doi.org/10.1117/12.401625


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