Linear lesions in heart tissue using diffused laser radiation

Nathaniel M. Fried; Albert C. Lardo; Ronald D. Berger; Hugh Calkins; Henry R. Halperin

doi:10.1117/12.386298

17 May 2000 Linear lesions in heart tissue using diffused laser radiation

Nathaniel M. Fried, Albert C. Lardo, Ronald D. Berger, Hugh Calkins, Henry R. Halperin

Proceedings Volume 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X; (2000) https://doi.org/10.1117/12.386298
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Transmural, continuous, and linear lesions may be necessary for successful catheter ablation of cardiac arrythmias such as atrial fibrillation. Laser ablation was studied as an alternative to radiofrequency ablation, which is noted to produce superficial and discontinuous lesions as well as tissue charring and vaporization. Samples of canine myocardium were placed in a saline bath and irradiated with an 1.06- micrometer Nd:YAG laser operated in either pulsed or continuous mode. For pulsed mode, the laser pulse duration was 10 s with 10 s cooling between pulses. Laser radiation was delivered radially through diffusing optical fiber tips oriented parallel to the endocardial surface. In CW mode, transmural (6-mm-deep), linear (16-mm-long), and continuous lesions were produced using a laser power of 30 W and an irradiation time of 180 s. Peak tissue temperatures measured 51 plus or minus 1 degree Celsius at the endocardial surface, 61 plus or minus 6 degrees Celsius in the mid-myocardium, and 55 plus or minus 6 degree Celsius at the epicardial surface. There was no evidence of tissue charring or vaporization. Pulsed laser irradiation produced comparable lesion depths to CW irradiation with more uniform heating of the subsurface myocardium, but at the expense of longer operation times. Further in vivo study of laser ablation is warranted for possible clinical applications.

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Nathaniel M. Fried, Albert C. Lardo, Ronald D. Berger, Hugh Calkins, and Henry R. Halperin "Linear lesions in heart tissue using diffused laser radiation", Proc. SPIE 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X, (17 May 2000); https://doi.org/10.1117/12.386298

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KEYWORDS

Tissues

Natural surfaces

Laser tissue interaction

Optical fibers

Laser ablation

Temperature metrology

Pulsed laser operation

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