Optical biopsy: in-vivo diagnosis of breast cancer using elastic scatter spectroscopy

David Christopher O. Pickard; Gavin M. Briggs; Christobel Saunders; Sunil Lakhani; Paul M. Ripley; Irving J. Bigio; Stephen G. Bown

doi:10.1117/12.386304

17 May 2000 Optical biopsy: in-vivo diagnosis of breast cancer using elastic scatter spectroscopy

David Christopher O. Pickard, Gavin M. Briggs, Christobel Saunders, Sunil Lakhani, Paul M. Ripley, Irving J. Bigio, Stephen G. Bown

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Proceedings Volume 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X; (2000) https://doi.org/10.1117/12.386304
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

Elastic scattering or diffuse reflectance spectroscopy offers the possibility of distinguishing between cancerous and non- cancerous tissue in the breast with a relatively simple optical measurement. The measurement of the relative reflection of light has previously been shown to be sensitive to both the size and distribution of intra and inter-cellular structures as well as absorption from chromophores, which are present in the tissue. Coupling a white light source and spectrometer to optic fibers makes it possible to construct probes that can be inserted percutaneously or used intra- operatively to take in-vivo spectra from breast tissue or ex- vivo spectra from excised sentinel nodes. This 'optical biopsy' is correlated with a conventional histopathological specimen obtained at the same point. Spectra are reported from a large number of patients with benign and malignant lesions. Some of the differences that appear in these spectra are outlined and the uses and limitations of this technique for in-vivo diagnosis are discussed. It is shown that to a relatively high degree of sensitivity and specificity it is possible to distinguish between malignant tumors, benign lesions and normal tissue.

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David Christopher O. Pickard, Gavin M. Briggs, Christobel Saunders, Sunil Lakhani, Paul M. Ripley, Irving J. Bigio, and Stephen G. Bown "Optical biopsy: in-vivo diagnosis of breast cancer using elastic scatter spectroscopy", Proc. SPIE 3907, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems X, (17 May 2000); https://doi.org/10.1117/12.386304

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KEYWORDS

Tissues

Biopsy

Tissue optics

Breast

Spectroscopy

Scattering

Breast cancer

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