Blue LEDs feasibility for tissue fluorescence analysis

Sergiy M. Dets; Nikolay A. Denisov

doi:10.1117/12.382725

19 April 2000 Blue LEDs feasibility for tissue fluorescence analysis

Sergiy M. Dets, Nikolay A. Denisov

Proceedings Volume 3917, Optical Biopsy III; (2000) https://doi.org/10.1117/12.382725
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

We considered the limited number of light-induced fluorescence applications for marketed ultra-bright blue LEDs where they can compete with versatile laser sources. Satisfactory optical output and miniature size as well as low power consumption of blue LEDs emitting at 470 nm allow to consider them as a promising alternatives to metal vapor or gas lasers used in many expires LIF applications. Available to authors LEDs form Hewlett-Packard, Micro Electronics Corp., Nichia Chemical Industries Ltd. and Toyoda Gosei Co. were tested to comply with demands to a tissue excitation source for portable spectroscopes. The optical performance of LEDs has shown that selected group of InGaN LEDs could be successfully used for that. The miniature illuminator that includes LED, focusing condenser, filter set and distal fiberoptic light concentrator was designed and tested in conjunction with portable CCD- equipped spectroscope. Operating in dark condition the proposed LED illuminator provides the level of fluorescence signal sufficient to detect spectral abnormalities in human Caucasian skin and excised gastrointestinal samples. All tissue autofluorescence data taken under LED illumination were compared with readings under He-Cd laser excitation and showed a good match. A new diagnostic designs based on LEDs were considered for clinical use.

Citation Download Citation

Sergiy M. Dets and Nikolay A. Denisov "Blue LEDs feasibility for tissue fluorescence analysis", Proc. SPIE 3917, Optical Biopsy III, (19 April 2000); https://doi.org/10.1117/12.382725

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