High-resolution x-ray CT screening of mutant mouse models

Michael J. Paulus; Shaun S. Gleason; Hamed Sari-Sarraf; Dabney K. Johnson; Charmaine J. Foltz; Derek W. Austin; M. Evangeline Easterly; Edward J. Michaud; Madhu S. Dhar; Patricia R. Hunsicker; J. W. Wall; M. Schell

doi:10.1117/12.384221

27 April 2000 High-resolution x-ray CT screening of mutant mouse models

Michael J. Paulus, Shaun S. Gleason, Hamed Sari-Sarraf, Dabney K. Johnson, Charmaine J. Foltz, Derek W. Austin, M. Evangeline Easterly, Edward J. Michaud, Madhu S. Dhar, Patricia R. Hunsicker, J. W. Wall, M. Schell

Author Affiliations +

Proceedings Volume 3921, Optical Diagnostics of Living Cells III; (2000) https://doi.org/10.1117/12.384221
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

A dedicated small animal x-ray computed tomography system has been developed to screen mutagenized mice for anatomical phenotypes. The key components of the data acquisition instrumentation are described along with the system performance parameters. Image reconstruction, visualization and segmentation software algorithms are described. Two contrast media regimens are described and representative studies of mice with adipose, soft and skeletal tissue abnormalities are presented.

Citation Download Citation

Michael J. Paulus, Shaun S. Gleason, Hamed Sari-Sarraf, Dabney K. Johnson, Charmaine J. Foltz, Derek W. Austin, M. Evangeline Easterly, Edward J. Michaud, Madhu S. Dhar, Patricia R. Hunsicker, J. W. Wall, and M. Schell "High-resolution x-ray CT screening of mutant mouse models", Proc. SPIE 3921, Optical Diagnostics of Living Cells III, (27 April 2000); https://doi.org/10.1117/12.384221

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available