New method for volumetric estimation of functioning thyroid tissue

David H. Feiglin; Andrzej Krol; George M. Gagne; Bradford J. Hellwig; Frank Deaver Thomas

doi:10.1117/12.383434

20 April 2000 New method for volumetric estimation of functioning thyroid tissue

David H. Feiglin, Andrzej Krol, George M. Gagne, Bradford J. Hellwig, Frank Deaver Thomas

Proceedings Volume 3978, Medical Imaging 2000: Physiology and Function from Multidimensional Images; (2000) https://doi.org/10.1117/12.383434
Event: Medical Imaging 2000, 2000, San Diego, CA, United States

Abstract

99m-Tc-pertechnetate SPECT studies of thyroid phantoms, with volumes in 13-198 cc range, and of a number of patients were performed. A modified reconstruction and analytic methods were applied to the data analysis. It involved: (1) transformation of the initial ECT data by a suitable mathematical function to compress the dynamical range of the data; (2) tomographic reconstruction resulting in transaxial (TV) images; (3) decompression of TV images via a reverse function; (4) Gaussian smoothing of the decompressed TV (dTV) images; (5) subtraction of a Compton dTV images from photopeak dTV images, (6) parallel operation on dTV images: Sobel edge detection and impulse filtering; (7) combining the filtered images via the AND operator; (8) edge tracing in the combined image by a human operator; (9) volume estimation by a computer. Based on the phantom studies it was established that the proposed technique yielded volumes with the relative error not exceeding 10%. For patient studies, the obtained volumes were also compared with palpation estimation. It has been found that inter-observer variability of the thyroid volume estimate is a function of physician's experience in utilization of manual palpation and it may result in the relative errors exceeding 50%.

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David H. Feiglin, Andrzej Krol, George M. Gagne, Bradford J. Hellwig, and Frank Deaver Thomas "New method for volumetric estimation of functioning thyroid tissue", Proc. SPIE 3978, Medical Imaging 2000: Physiology and Function from Multidimensional Images, (20 April 2000); https://doi.org/10.1117/12.383434

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KEYWORDS

Single photon emission computed tomography

Image filtering

Tissues

Gaussian filters

Edge detection

Error analysis

Tomography

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