Laser-induced thermotherapy (LITT): energy and temperature determination for complete in-situ ablation of liver metastasis

Christoph Martin Isbert; Andre Roggan; Joerg-Peter Ritz; Gerhard J. Mueller; Heinz-Johannes Buhr; Kai-S. Lehmann; Christoph-Thomas Germer

doi:10.1117/12.409314

16 November 2000 Laser-induced thermotherapy (LITT): energy and temperature determination for complete in-situ ablation of liver metastasis

Christoph Martin Isbert, Andre Roggan, Joerg-Peter Ritz, Gerhard J. Mueller, Heinz-Johannes Buhr, Kai-S. Lehmann, Christoph-Thomas Germer

Author Affiliations +

Proceedings Volume 4161, Optical Biopsy and Tissue Optics; (2000) https://doi.org/10.1117/12.409314
Event: EOS/SPIE European Biomedical Optics Week, 2000, Amsterdam, Netherlands

Abstract

Purpose: The aim of this study was to determine the energy (J/mm³ tumor volume) and temperature required for a complete in-situ-ablation of experimental liver tumors. Methods: LITT was performed in VX-2 tumor-bearing rabbits using Nd-YAG-Laser (1064 nm) with a diffuser-tip applicator and a temperature feedback-system. The animals were randomized into 4 groups (n equals 20) that differed in the target temperature at the tumor border [45 degrees Celsius, 50 degrees Celsius, 55 degrees Celsius and 60 degrees Celsius]. Histological examination was done at 0 h, 24 h, 96 h and 14 days after LITT. Results: The pretreatment tumor volume of 2191 +/- 61 mm³ was the same for all groups (p > 0.05). Energy and temperature required and the rate of incomplete tumor-ablation (recurrences) are listed below (* equals p < 0.05, Kruskal-Wallis test. Conclusions: (1) To achieve complete in-situ-ablation under the given conditions, it is necessary to apply laser-energy of 3 J/mm³ tumor volume. (2) A minimum temperature of 60 degrees Celsius on the tumor border presumed an application of 10 minutes.

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Christoph Martin Isbert, Andre Roggan, Joerg-Peter Ritz, Gerhard J. Mueller, Heinz-Johannes Buhr, Kai-S. Lehmann, and Christoph-Thomas Germer "Laser-induced thermotherapy (LITT): energy and temperature determination for complete in-situ ablation of liver metastasis", Proc. SPIE 4161, Optical Biopsy and Tissue Optics, (16 November 2000); https://doi.org/10.1117/12.409314

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