Vascular plaque characterization using intravascular ultrasound elastography and NIR Raman spectroscopy in vitro

Chris L. de Korte; Hendrik P. J. Buschman; Sweder W. E. van de Poll; Anton F. W. van der Steen; Gerwin J. Puppels; Arnoud van der Laarse

doi:10.1117/12.382223

12 April 2000 Vascular plaque characterization using intravascular ultrasound elastography and NIR Raman spectroscopy in vitro

Chris L. de Korte, Hendrik P. J. Buschman, Sweder W. E. van de Poll, Anton F. W. van der Steen, Gerwin J. Puppels, Arnoud van der Laarse

Author Affiliations +

Proceedings Volume 3982, Medical Imaging 2000: Ultrasonic Imaging and Signal Processing; (2000) https://doi.org/10.1117/12.382223
Event: Medical Imaging 2000, 2000, San Diego, CA, United States

Abstract

The composition and morphology of the atherosclerotic lesion are considered to be important determinants of acute coronary ischemic syndromes. We investigated the potentials of a combination of intravascular ultrasound (IVUS) elastography and intravascular Near Infrared Raman (NIR) spectroscopy, to assess the physical and chemical composition of the vessel wall and plaque. Intact human coronary arteries were mounted in an in vitro pressurized perfusion setup and investigated with a 20 MHz Visions^R IVUS catheter. At selected cross- sections, two echo-frames were acquired at intraluminal pressures of 80 and 100 mmHg to strain the tissue in order to obtain elastograms. Next, Raman spectra were obtained during 30 seconds at 4 angles (0, 90, 180 and 270 degrees) using a sideways viewing probe. Spectra were modeled to obtain quantitative chemical information, while leaving the specimens intact. Calcified areas were identifiable on the echograms, elastograms and Raman spectra. A combination of geometric information provided by the echogram, chemical information as obtained with Raman spectroscopy, and high stress regions determined by the elastogram, may prove to be a valuable tool to identify plaque vulnerability.

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Chris L. de Korte, Hendrik P. J. Buschman, Sweder W. E. van de Poll, Anton F. W. van der Steen, Gerwin J. Puppels, and Arnoud van der Laarse "Vascular plaque characterization using intravascular ultrasound elastography and NIR Raman spectroscopy in vitro", Proc. SPIE 3982, Medical Imaging 2000: Ultrasonic Imaging and Signal Processing, (12 April 2000); https://doi.org/10.1117/12.382223

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