Quantitative detection of hemoglobin saturation on piglet brain by near-infrared frequency-domain spectroscopy

Congwu Du; Carol Andersen; Britton Chance

doi:10.1117/12.301089

1 January 1998 Quantitative detection of hemoglobin saturation on piglet brain by near-infrared frequency-domain spectroscopy

Congwu Du, Carol Andersen, Britton Chance

Author Affiliations +

Proceedings Volume 3194, Photon Propagation in Tissues III; (1998) https://doi.org/10.1117/12.301089
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

An approach of using phase modulation spectroscopy (PMS) system has been proposed which has single frequency, dual- wavelength with phase-only output for oximetry to minimize the influences of room light in the clinical environment. The availability of this method has been verified by laboratory experiments both in vitro and in vivo. In this study, a 200 Mhz PMS system has been used for measuring on piglet brain in vivo, to detect blood volume and saturation change during normoxia to hypoxia periods, and to monitor the brain depolarization in the hypoxic stress. Our experimental results show that the brain saturation estimated by PMS is approximately 84% and lies between arterial and venous blood values of 97% and 80% in normoxia, and tends to move close to the venous side in hypoxia. In addition, the excessive hypoxic stress triggers the brain to be bio-energetic deficits and finally introduced the neural depolarization, which can be effectively detected by recording the increment of tissue scattering.

Citation Download Citation

Congwu Du, Carol Andersen, and Britton Chance "Quantitative detection of hemoglobin saturation on piglet brain by near-infrared frequency-domain spectroscopy", Proc. SPIE 3194, Photon Propagation in Tissues III, (1 January 1998); https://doi.org/10.1117/12.301089

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