Effects of nitric oxide and its synthesis inhibitor on neuron efficiency detected by a fiber-optic-based multisensor

Zheng Shen; Jun Hua; Shuzhi Lin; Xiangfeng Liu

doi:10.1117/12.297927

13 January 1998 Effects of nitric oxide and its synthesis inhibitor on neuron efficiency detected by a fiber-optic-based multisensor

Zheng Shen, Jun Hua, Shuzhi Lin, Xiangfeng Liu

Author Affiliations +

Proceedings Volume 3196, Optical and Imaging Techniques for Biomonitoring III; (1998) https://doi.org/10.1117/12.297927
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

Sodium nitroprusside (SNP) as an exogenous nitric oxide (NO) donor and N(omega) -nitro-L-arginine methyl ester(L-NAME) as NO synthesis inhibitor was driven into monkey cortex by iontophoresis, their effects on face recognition of monkey were observed, and neuron firing as well as neuron efficiency were monitored by fiberoptic-based multisensor during face recognition. The results show that L-NAME and low dose of SNP(5 nM) did not have any significant effect on face recognition and neuron efficiency, however high dose of SNP(50 nM) increased simultaneously both correct rate of face recognition and neuron efficiency, but not neuron firing. The results were discussed according to NO and its synthesis mechanism.

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Zheng Shen, Jun Hua, Shuzhi Lin, and Xiangfeng Liu "Effects of nitric oxide and its synthesis inhibitor on neuron efficiency detected by a fiber-optic-based multisensor", Proc. SPIE 3196, Optical and Imaging Techniques for Biomonitoring III, (13 January 1998); https://doi.org/10.1117/12.297927

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