X-ray microscopy with compact pulsed sources

Martin C. Richardson; Masataka Kado; David Scott Torres; Yoshimasa Yamamoto; Herman Friedman; Jayshree Rajyaguru; Michael J. Muszynski

doi:10.1117/12.300073

1 March 1998 X-ray microscopy with compact pulsed sources

Martin C. Richardson, Masataka Kado, David Scott Torres, Yoshimasa Yamamoto, Herman Friedman, Jayshree Rajyaguru, Michael J. Muszynski

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Proceedings Volume 3240, 26th AIPR Workshop: Exploiting New Image Sources and Sensors; (1998) https://doi.org/10.1117/12.300073
Event: 26th AIPR Workshop: Exploiting New Image Sources and Sensors, 1997, Washington, DC, United States

Abstract

X-ray microscopy inherently possesses characteristics complementary to optical and electron microscopy. Short wavelength x-ray radiation, especially in the so-called 'water window', permits a twenty-fold improvement in spatial resolution over optical microscopy while preserving a depth of field large enough to image whole biological specimens int heir natural state. Whereas electron microscopy can access atomic-scale resolution,this can only be applied to biological and medical specimens at the expense of detrimental preparation procedures that preclude real-time analysis of structural changes in living organisms. We describe progress being made in an x-ray imaging technology that provides high-resolution single frame x-ray images of in-vitro specimens captured in a time sufficiently short that any radiation damage mechanisms to the structure are not recorded. Several different biology and medical research groups find this type of microscopy particularly well-suited to the detailed analysis of sub-cellular features, and to the study of live organisms subjected to various forms of external stimuli. This technology utilizes bright x-ray sources produced by compact pulse laser systems. The incorporation of advanced x-ray optical and electron-optical systems will lead to the development of a compact, real-time x-ray microscope, having a broad range of applications.

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Martin C. Richardson, Masataka Kado, David Scott Torres, Yoshimasa Yamamoto, Herman Friedman, Jayshree Rajyaguru, and Michael J. Muszynski "X-ray microscopy with compact pulsed sources", Proc. SPIE 3240, 26th AIPR Workshop: Exploiting New Image Sources and Sensors, (1 March 1998); https://doi.org/10.1117/12.300073

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KEYWORDS

X-ray microscopy

X-rays

X-ray optics

X-ray technology

Analytical research

Biological research

Electron microscopy

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