Integrated endoscopic OCT system and in-vivo images of human internal organs

Alexander M. Sergeev; Valentin M. Gelikonov; Grigory V. Gelikonov; Felix I. Feldchtein; Roman V. Kuranov; Natalia D. Gladkova; Natalia M. Shakhova; Ludmila Snopova; Andrei Shakhov; Irina N. Kuznetzova; Arkady Denisenko; Vitaly Pochinko; Yuri Chumakov; Valentin Almasov

doi:10.1117/12.306067

24 April 1998 Integrated endoscopic OCT system and in-vivo images of human internal organs

Alexander M. Sergeev, Valentin M. Gelikonov, Grigory V. Gelikonov, Felix I. Feldchtein, Roman V. Kuranov, Natalia D. Gladkova, Natalia M. Shakhova, Ludmila Snopova, Andrei Shakhov, Irina N. Kuznetzova, Arkady Denisenko, Vitaly Pochinko, Yuri Chumakov, Valentin Almasov

Author Affiliations +

Proceedings Volume 3251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II; (1998) https://doi.org/10.1117/12.306067
Event: BiOS '98 International Biomedical Optics Symposium, 1998, San Jose, CA, United States

Abstract

First results of endoscopic applications of optical coherence tomography (OCT) for in vivo studies of human mucosa in respiratory, gastrointestinal, urinary and genital tracts are presented. A novel endoscopic OCT (EOCT) system has been created that is based on the integration of a sampling arm of an all-optical-fiber interferometer into standard endoscopic devices using their biopsy channel to transmit low-coherence radiation to investigated tissue. We have studied mucous membranes of esophagus, larynx, stomach, urinary bladder, uterine cervix and endometrium as typical localization for carcinomatous processes. Images of tumor tissues versus healthy tissues have been recorded and analyzed. Violations of well-defined stratified healthy mucosa structure in cancered tissue is distinctly seen by EOCT, thus making this technique promising for early diagnosis of tumors and precise guiding of excisional biopsy.

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Alexander M. Sergeev, Valentin M. Gelikonov, Grigory V. Gelikonov, Felix I. Feldchtein, Roman V. Kuranov, Natalia D. Gladkova, Natalia M. Shakhova, Ludmila Snopova, Andrei Shakhov, Irina N. Kuznetzova, Arkady Denisenko, Vitaly Pochinko, Yuri Chumakov, and Valentin Almasov "Integrated endoscopic OCT system and in-vivo images of human internal organs", Proc. SPIE 3251, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II, (24 April 1998); https://doi.org/10.1117/12.306067

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