Diagnostic methods and tissue parameter investigations together with measurement results (in vivo)

Matthias Dieckmann; Karsten Dierks

doi:10.1117/12.178569

23 June 1994 Diagnostic methods and tissue parameter investigations together with measurement results (in vivo)

Matthias Dieckmann, Karsten Dierks

Proceedings Volume 2126, Ophthalmic Technologies IV; (1994) https://doi.org/10.1117/12.178569
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

In course of instrumentation technology developments for spaceborne experiments under microgravity in areas of nucleation control during crystal growth and critical point phenomena, miniaturized optrodes were achieved. Described optrodes can be easily integrated into ophthalmoscopes as well. By combination of monomode-fibres and focusing lenses, light source powers were minimized and photon correlation spectroscopy (PCS) measurements were conducted with lowest intensity levels on human eye lenses. In vivo measurements enabled resolution of various radii fractions. Detailed analysis and applied statistical categorization of results are described. Measurements are evaluated for the first time with a 288-channel real-time correlator. PCS is studied concerning baseline determination addressing multi-exponential fit procedures. Potential extensions of PCS to developments of simultaneous multi-angle profilometry are indicated. Approaches to aggregation mapping are presented, addressing demands of depth related resolution within scattering volumes. Velocity studies reflecting local blood propagation, achieved by described opto-electronics on possibly different capillary diameters are included. Interpretations are given concerning distortions observed at sections of measured autocorrelation functions.

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Matthias Dieckmann and Karsten Dierks "Diagnostic methods and tissue parameter investigations together with measurement results (in vivo)", Proc. SPIE 2126, Ophthalmic Technologies IV, (23 June 1994); https://doi.org/10.1117/12.178569

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