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Proceedings Article

Average depth of blood vessels in skin and lesions deduced by optical fiber spectroscopy

[+] Author Affiliations
Steven L. Jacques

Univ. of Texas M.D. Anderson Cancer Ctr. and Rice Univ. (USA)

Iyad S. Saidi

Baylor College of Medicine and Rice Univ. (USA)

Frank K. Tittel

Rice Univ. (USA)

Proc. SPIE 2128, Laser Surgery: Advanced Characterization, Therapeutics, and Systems IV, 231 (September 7, 1994); doi:10.1117/12.184904
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From Conference Volume 2128

  • Laser Surgery: Advanced Characterization, Therapeutics, and Systems IV
  • R. Rox Anderson
  • Los Angeles, CA | January 23, 1994

abstract

The average depth of blood vessels in a cutaneous site, either normal or diseased, can be specified by a simple rapid noninvasive optical measurement. An optical fiber spectrophotometer delivers white light via optical fibers to a skin site. The light reflected by tissue scattering and successfully collected by optical fibers is carried to a diode array spectrophotometer for spectral analysis. The reflectance spectrum is analyzed to specify the component of the optical density (OD) spectrum which is attributed to the cutaneous blood. Then the ratio of the OD420 nm/OD585 nm provides a quantitative indication of the average depth of the blood in the skin site. The purple light (420 nm) less easily penetrates the skin to sample the cutaneous blood content than does the yellow light (585 nm). The calibration of the measurement was accomplished by Monte Carlo simulations of measurements on skin with a layer of blood at various depths. In a study of 47 neonates, the amount of blood content ranged from 4 - 12 mg hemoglobin/g tissue (equivalent to 0.8 - 2.4% of the skin volume being whole blood), and the average depth of blood ranged from 250 - 425 micrometers .

© (1994) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Steven L. Jacques ; Iyad S. Saidi and Frank K. Tittel
"Average depth of blood vessels in skin and lesions deduced by optical fiber spectroscopy", Proc. SPIE 2128, Laser Surgery: Advanced Characterization, Therapeutics, and Systems IV, 231 (September 7, 1994); doi:10.1117/12.184904; http://dx.doi.org/10.1117/12.184904


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