Fluorescence spectroscopy for diagnosis of esophageal cancer

Masoud Panjehpour; Bergein F. Overholt M.D.; Tuan Vo-Dinh; Christie Farris; James L. Schmidhammer; Rick E. Sneed; Paul F. Buckley III

doi:10.1117/12.179982

19 July 1994 Fluorescence spectroscopy for diagnosis of esophageal cancer

Masoud Panjehpour, Bergein F. Overholt M.D., Tuan Vo-Dinh, Christie Farris, James L. Schmidhammer, Rick E. Sneed, Paul F. Buckley III

Author Affiliations +

Proceedings Volume 2133, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III; (1994) https://doi.org/10.1117/12.179982
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

Laser-induced fluorescence spectroscopy was employed to measure fluorescence emission of normal and malignant tissue during endoscopy in patients with esophageal adenocarcinoma. A nitrogen/dye laser tuned at 410 nm was used for excitation source. The fluorescence lineshape of each spectrum was determined and sampled at 15 nm intervals from 430 nm to 716 nm. A calibration set from normal and malignant spectra were selected. Using stepwise discriminate analysis, significant wavelengths that separated normal and malignant spectra were selected. The intensities at these wavelengths were used to formulate a classification model using linear discriminate analysis. The model was used to classify additional tissue spectra from 26 malignant and 108 normal sites into either normal or malignant spectra with a sensitivity of 100 percent and specificity of 98 percent.

Citation Download Citation

Masoud Panjehpour, Bergein F. Overholt M.D., Tuan Vo-Dinh, Christie Farris, James L. Schmidhammer, Rick E. Sneed, and Paul F. Buckley III "Fluorescence spectroscopy for diagnosis of esophageal cancer", Proc. SPIE 2133, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy III, (19 July 1994); https://doi.org/10.1117/12.179982

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available