Tissue autofluorescence spectroscopy: in-vivo alterations may reflect cellular proliferation

Howard E. Savage; Venkateswara Kolli; Jian Chung Zhang M.D.; Robert R. Alfano; Peter G. Sacks; Stimson P. Schantz M.D.

doi:10.1117/12.175991

19 May 1994 Tissue autofluorescence spectroscopy: in-vivo alterations may reflect cellular proliferation

Howard E. Savage, Venkateswara Kolli, Jian Chung Zhang M.D., Robert R. Alfano, Peter G. Sacks, Stimson P. Schantz M.D.

Proceedings Volume 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases; (1994) https://doi.org/10.1117/12.175991
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

We report on the in vivo fluorescence spectroscopy of ten oral tongue cancers in previously untreated patients. Spectral profiles of the tongue tumor in each patient were compared to those of the corresponding normal contralateral oral tongue mucosa. Spectral characteristics were generated using a xenon lamp as a light source and the results described herein were restricted to one excitation scan obtained using a Mediscience-CD Scanner. The ratio of the main peak at 320-350 nm to the secondary peak at 373-376 nm and the area under the curve between 300 and 400 nm in the excitation scan were used as measurements to calculate differences between the normal versus oral tongue cancer. Significance was determined using the paired t-st. The ratio of the main peak to the secondary peak was higher in the tumor scans when compared to the corresponding contralateral mucosa. When the area under the curves was analyzed, the tumor tissue had reproducible lower values as compared to the contralateral normal sites.

Citation Download Citation

Howard E. Savage, Venkateswara Kolli, Jian Chung Zhang M.D., Robert R. Alfano, Peter G. Sacks, and Stimson P. Schantz M.D. "Tissue autofluorescence spectroscopy: in-vivo alterations may reflect cellular proliferation", Proc. SPIE 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, (19 May 1994); https://doi.org/10.1117/12.175991

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available