Three-dimensional lung morphogenesis and fractal analysis as tools for the quantification of lung disease

Jiang Qian; Theophano Mitsa

doi:10.1117/12.174407

1 May 1994 Three-dimensional lung morphogenesis and fractal analysis as tools for the quantification of lung disease

Jiang Qian, Theophano Mitsa

Proceedings Volume 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images; (1994) https://doi.org/10.1117/12.174407
Event: Medical Imaging 1994, 1994, Newport Beach, CA, United States

Abstract

The bronchial tree is one of the most well known fractal structures in the human body. Fractal objects like the bronchial tree have complex structures with self-similar properties over different scales. In this paper, we present a 3-D bronchial tree computer model constructed using fractal growth rules and actual morphometric data. Given the important role that the chest walls play in lung morphogenesis, the growth of the model was constrained within a 3-D boundary extracted from high resolution CT (HRCT) lung data. The model was built within a space of (512 X 512 X 512) pixels, and it currently models only the right lung. The parameters of the model are: (1) the diameter, d, of a branch; (2) the length, l, of a branch; (3) the angle, (theta) , between a branch and its parent. Utilizing this model as a testground, we developed a functional relationship between different changes in the morphology of the bronchial tree and the values of its 3-D fractal dimension and 3-D lacunarity.

Citation Download Citation

Jiang Qian and Theophano Mitsa "Three-dimensional lung morphogenesis and fractal analysis as tools for the quantification of lung disease", Proc. SPIE 2168, Medical Imaging 1994: Physiology and Function from Multidimensional Images, (1 May 1994); https://doi.org/10.1117/12.174407

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