Changes in collagen birefringence: a quantitative histologic marker of thermal damage in skin

Sharon L. Thomsen M.D.; Wai-Fung Cheong; John Anthony Pearce

doi:10.1117/12.43938

1 June 1991 Changes in collagen birefringence: a quantitative histologic marker of thermal damage in skin

Sharon L. Thomsen M.D., Wai-Fung Cheong, John Anthony Pearce

Proceedings Volume 1422, Lasers in Dermatology and Tissue Welding; (1991) https://doi.org/10.1117/12.43938
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

Quantitative histologic markers of thermal damage in collagen include changes of intensity and color shifts of birefringent images and hyalinization of collagen fibers using transmission polarizing microscopy (TPM) and light microscopy (LM). These changes are seen in routinely prepared paraffin histologic sections stained with dyes readily available in most pathology and histology laboratories. The quantitative histologic markers of thermal damage have been used to map extent of thermal injury and promise to be useful for investigations of the mechanisms of photothermal laser-tissue interactions.

Citation Download Citation

Sharon L. Thomsen M.D., Wai-Fung Cheong, and John Anthony Pearce "Changes in collagen birefringence: a quantitative histologic marker of thermal damage in skin", Proc. SPIE 1422, Lasers in Dermatology and Tissue Welding, (1 June 1991); https://doi.org/10.1117/12.43938

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