Tissue perfusion monitoring and imaging by coherent light scattering

Gert E. Nilsson; Anneli Jakobsson; Karin Wardell

doi:10.1117/12.57709

1 March 1992 Tissue perfusion monitoring and imaging by coherent light scattering

Gert E. Nilsson, Anneli Jakobsson, Karin Wardell

Proceedings Volume 1524, Bioptics: Optics in Biomedicine and Environmental Sciences; (1992) https://doi.org/10.1117/12.57709
Event: Bioptics: Optics in Biomedicine and Environmental Studies, 1991, Porto, Portugal

Abstract

Quasielastic scattering of coherent light in tissue can be utilized to probe the superficial blood flow of the skin and other organs. This fundamental principle has been employed in the construction of laser Doppler tissue perfusion monitors and imagers, intended for experimental and clinical investigations of tissue blood flow. In this paper, the theory of laser Doppler equipment is discussed. The measuring depth can be estimated by Monte Carlo simulation, while the dynamic light scattering (light scattering including Doppler effects) can be modeled by autocorrelation techniques. Based on these techniques estimators for tissue perfusion and tissue blood cell concentration are derived. The operating principle of the laser Doppler monitor is described in detail, with special reference to the design of probes. This monitor is useful for tracking temporal changes in tissue perfusion at a single point. The principle of a recently developed laser Doppler perfusion imager is reviewed. This imager is useful in mapping the spatial variations in tissue perfusion. Different ways of evaluating the performances of the monitor and imager in both mechanical flow simulators and in-vivo studies are discussed. Finally a brief overview is made of some fields of application in which the laser Doppler technique for measurement of tissue perfusion has been successfully used.

Citation Download Citation

Gert E. Nilsson, Anneli Jakobsson, and Karin Wardell "Tissue perfusion monitoring and imaging by coherent light scattering", Proc. SPIE 1524, Bioptics: Optics in Biomedicine and Environmental Sciences, (1 March 1992); https://doi.org/10.1117/12.57709

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