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Proceedings Article

Two- and three-dimensional optical tomography of finger joints for diagnostics of rheumatoid arthritis

[+] Author Affiliations
Alexander D. Klose, Andreas H. Hielscher

SUNY/Brooklyn Health Science Ctr. (USA)

Kenneth M. Hanson

Los Alamos National Lab. (USA)

Juergen Beuthan

Institut fuer Medizinische/Technische Physik und Lasermedizin/Freie Univ. Berlin (Germany)

Proc. SPIE 3566, Photon Propagation in Tissues IV, 151 (December 30, 1998); doi:10.1117/12.334363
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From Conference Volume 3566

  • Photon Propagation in Tissues IV
  • David A. Benaron; Britton Chance; Marco Ferrari; Matthias Kohl-Bareis
  • Stockholm, Sweden | September 08, 1998

abstract

Rheumatoid arthritis (RA) is one of the most common diseases of human joints. This progressive disease is characterized by an inflammation process that originates in the inner membrane (synovalis) of the capsule and spreads to other parts of the joint. In early stages the synovalis thickness and the permeability of this membrane changes. This leads to changes in the optical parameters of the synovalis and the synovial fluid (synovia), which occupies the space between the bones. The synovia changes from a clear yellowish fluid to a turbid grayish substance. In this work we present 2 and 3-dimensional reconstruction schemes for optical tomography of the finger joints. Our reconstruction algorithm is based on the diffusion approximation and employs adjoint differentiation techniques for the gradient calculation of the objective function with respect to the spatial distribution of optical properties. In this way, the spatial distribution of optical properties within the joints is reconstructed with high efficiency and precision. Volume information concerning the synovial space and the capsula are provided. Furthermore, it is shown that small changes of the scattering coefficients can be monitored. Therefore, optical tomography has the potential of becoming a useful tool for the early diagnosis and monitoring of disease progression in RA.

© (1998) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Citation

Alexander D. Klose ; Andreas H. Hielscher ; Kenneth M. Hanson and Juergen Beuthan
"Two- and three-dimensional optical tomography of finger joints for diagnostics of rheumatoid arthritis", Proc. SPIE 3566, Photon Propagation in Tissues IV, 151 (December 30, 1998); doi:10.1117/12.334363; http://dx.doi.org/10.1117/12.334363


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