Tissue diagnostics using fiber optic FTIR spectroscopy

Uwe Bindig; Wolfgang Waesche; K. Liebold; Harald Winter; Ulrich M. Gross; P. Frege; G. Mueller

doi:10.1117/12.336815

19 January 1999 Tissue diagnostics using fiber optic FTIR spectroscopy

Uwe Bindig, Wolfgang Waesche, K. Liebold, Harald Winter, Ulrich M. Gross, P. Frege, G. Mueller

Proceedings Volume 3568, Optical Biopsies and Microscopic Techniques III; (1999) https://doi.org/10.1117/12.336815
Event: BiOS Europe '98, 1998, Stockholm, Sweden

Abstract

The infrared spectrum of biological tissue is due to the 'microheterogenous' composition as a whole and is based on complex vibrational modes. In detail, the spectrum represents the biochemical status resulting from a combination of the structural framework of tissues together with the biological active compounds of metabolism. According to the literature, the main IR-spectroscopic differences are to be expected by the characteristic spectral pattern which is located at the 'fingerprint' region (1500 - 1000 cm^-1). In order to design and develop an endoscopic system for the in vivo identification of healthy and malignant tissue FTIR- measurements were carried out using a fiberoptic device. The source of IR-radiation can be either the FTIR-spectrometer or tunable IR-diode lasers. Fiberoptic IR-spectra obtained using the attenuated total reflectance (ATR) and reflection mode were compared to spectra resulting from the FTIR- microspectroscopic measurements.

Citation Download Citation

Uwe Bindig, Wolfgang Waesche, K. Liebold, Harald Winter, Ulrich M. Gross, P. Frege, and G. Mueller "Tissue diagnostics using fiber optic FTIR spectroscopy", Proc. SPIE 3568, Optical Biopsies and Microscopic Techniques III, (19 January 1999); https://doi.org/10.1117/12.336815

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