Miniature fiber optic surface plasmon resonance biosensors

Radan Slavik; Eduard Brynda; Jiri Homola; Jiri Ctyroky

doi:10.1117/12.336929

15 January 1999 Miniature fiber optic surface plasmon resonance biosensors

Radan Slavik, Eduard Brynda, Jiri Homola, Jiri Ctyroky

Proceedings Volume 3570, Biomedical Sensors, Fibers, and Optical Delivery Systems; (1999) https://doi.org/10.1117/12.336929
Event: BiOS Europe '98, 1998, Stockholm, Sweden

Abstract

A novel design of surface plasmon resonance fiber optic sensor is reported which leads to a compact, highly miniaturized sensing element with excellent sensitivity. The sensing device is based on a side-polished single-mode optical fiber with a thin metal overlayer supporting surface plasmon waves. The strength of interaction between a fiber mode and a surface plasmon wave depends strongly on the refractive index near the sensing surface. Therefore, refractive index changes associated with biospecific interaction between antibodies immobilized on the sensor and antigen molecules can be monitored by measuring light intensity variations. Detection of horse radish peroxidase (HRP) of the concentration of 100 ng/ml has been accomplished using the fiber optic sensor with a matrix of monoclonal antibodies against HRP immobilized on the sensor surface.

Citation Download Citation

Radan Slavik, Eduard Brynda, Jiri Homola, and Jiri Ctyroky "Miniature fiber optic surface plasmon resonance biosensors", Proc. SPIE 3570, Biomedical Sensors, Fibers, and Optical Delivery Systems, (15 January 1999); https://doi.org/10.1117/12.336929

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available