Diagnostics of breast cancer tissue by fiber optic evanescent wave Fourier transform IR (FEW-FTIR) spectroscopy

Natalia I. Afanasyeva; Volodymyr Makhine; Reinhard F. Bruch

doi:10.1117/12.351003

22 June 1999 Diagnostics of breast cancer tissue by fiber optic evanescent wave Fourier transform IR (FEW-FTIR) spectroscopy

Natalia I. Afanasyeva, Volodymyr Makhine, Reinhard F. Bruch

Author Affiliations +

Proceedings Volume 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX; (1999) https://doi.org/10.1117/12.351003
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Fourier transform IR fiberoptic evanescent wave (FTIR-FEW) spectroscopy has been suggested as a powerful tool for clinical diagnostics of normal, pre-cancerous, and cancerous breast tissue ex vivo and in vitro in the middle IR region of the spectrum(850-1850 cm^-1). This method is suitable for noninvasive and direct measurements of the spectra of normal and pathological tissues in vitro, ex vivo and in vivo. For the first time this method has been use nondestructively, rapidly, fast (15-20 sec) and remotely in the operating rooms of clinics. The aim of our studies has been the on-line testing of various tumor tissues during surgery to optimize and localize an area to remove tissue. We measured very small samples of normal and malignant breast tissue ex vivo with a fiber bent to a special angle, forming a special tip probe configuration. We also suggest here the minimally invasive FTIR-FEW diagnosis tool using 'needle' changeable tip probe for biopsy applications. The corresponding spectral histopathology scheme could be developed with help of this technique in vitro. The breast tissue at different stages of tumor or cancer has been distinguished very clearly in spectra of amide, cyclic and non-cyclic hydrogen bonded fragments, phosphate groups and sugars.

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Natalia I. Afanasyeva, Volodymyr Makhine, and Reinhard F. Bruch "Diagnostics of breast cancer tissue by fiber optic evanescent wave Fourier transform IR (FEW-FTIR) spectroscopy", Proc. SPIE 3590, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems IX, (22 June 1999); https://doi.org/10.1117/12.351003

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