Mapping of thermal injury in biologic tissues using quantitative pathologic techniques

Sharon L. Thomsen M.D.

doi:10.1117/12.348748

19 May 1999 Mapping of thermal injury in biologic tissues using quantitative pathologic techniques

Sharon L. Thomsen M.D.

Proceedings Volume 3594, Thermal Treatment of Tissue with Image Guidance; (1999) https://doi.org/10.1117/12.348748
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Qualitative and quantitative pathologic techniques can be used for (1) mapping of thermal injury, (2) comparisons lesion sizes and configurations for different instruments or heating sources and (3) comparisons of treatment effects. Concentric zones of thermal damage form around a single volume heat source. The boundaries between some of these zones are distinct and measurable. Depending on the energy deposition, heating times and tissue type, the zones can include the following beginning at the hotter center and progressing to the cooler periphery: (1) tissue ablation, (2) carbonization, (3) tissue water vaporization, (4) structural protein denaturation (thermal coagulation), (5) vital enzyme protein denaturation, (6) cell membrane disruption, (7) hemorrhage, hemostasis and hyperhemia, (8) tissue necrosis and (9) wound organization and healing.

Citation Download Citation

Sharon L. Thomsen M.D. "Mapping of thermal injury in biologic tissues using quantitative pathologic techniques", Proc. SPIE 3594, Thermal Treatment of Tissue with Image Guidance, (19 May 1999); https://doi.org/10.1117/12.348748

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