MR-guided noninvasive thermal coagulation of in-vivo liver tissue using ultrasonic phased array

Douglas R. Daum; Nadine Smith; Nathan McDannold; Kullervo H. Hynynen

doi:10.1117/12.348738

19 May 1999 MR-guided noninvasive thermal coagulation of in-vivo liver tissue using ultrasonic phased array

Douglas R. Daum, Nadine Smith, Nathan McDannold, Kullervo H. Hynynen

Proceedings Volume 3594, Thermal Treatment of Tissue with Image Guidance; (1999) https://doi.org/10.1117/12.348738
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

Magnetic resonance (MR) imaging was used to guide and monitor the thermal tissue coagulation of in vivo porcine tissue using a 256 element ultrasonic phased array. The array could coagulate tissue volumes greater than 2 cm³ in liver and 0.5 cm³ in kidney using a single 20 second sonication. This sonication used multiple focus fields which were temporally cycled to heat large tissue volumes simultaneously. Estimates of the coagulated tissue using a thermal dose threshold compare well with T2-weighted images of post sonication lesions. The overlapping large focal volumes could aid in the treatment of large tumor volumes which require multiple overlapping sonications. The ability of MR to detect the presence and undesirable thermal increases at acoustic obstacle such as cartilaginous and bony ribs is demonstrated. This could have a significant impact on the ability to monitor thermal treatments of the liver and other organs which are acoustically blocked.

Citation Download Citation

Douglas R. Daum, Nadine Smith, Nathan McDannold, and Kullervo H. Hynynen "MR-guided noninvasive thermal coagulation of in-vivo liver tissue using ultrasonic phased array", Proc. SPIE 3594, Thermal Treatment of Tissue with Image Guidance, (19 May 1999); https://doi.org/10.1117/12.348738

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