Raman spectroscopy as a diagnostic probe for ancient skin

Howell G.M. Edwards

doi:10.1117/12.345388

9 April 1999 Raman spectroscopy as a diagnostic probe for ancient skin

Howell G.M. Edwards

Proceedings Volume 3608, Biomedical Applications of Raman Spectroscopy; (1999) https://doi.org/10.1117/12.345388
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

We discuss the use of Raman microprobe spectroscopy and Raman imaging to study the chemical composition of fresh, unmounted bone at a microscopic level. A specimen of human cortical bone was analyzed and evidence for the presence of amorphous-type calcium phosphate, a theoretical precursor in the bone formation process, was found. In general the amorphous-type calcium phosphate appears away from osteons, in the interstitial tissue. This finding calls into question the role of amorphous-type calcium phosphate as a precursor to apatitic phosphate, since it was not found in the recently remodeled bone near the osteon center, but rather in older bone tissue. Some reasons for the presence of amorphous calcium phosphate are proposed. Possible relations of the amorphous mineral to bone damage and bone remodeling are discussed.

Citation Download Citation

Howell G.M. Edwards "Raman spectroscopy as a diagnostic probe for ancient skin", Proc. SPIE 3608, Biomedical Applications of Raman Spectroscopy, (9 April 1999); https://doi.org/10.1117/12.345388

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