Discrepancy between photodynamic injuries and pheophorbide A accumulation in digestive tissues

S. Evrard; M. Koenig; C. Damge; Jacques Marescaux; M. Aprahamian

doi:10.1117/12.199146

12 January 1995 Discrepancy between photodynamic injuries and pheophorbide A accumulation in digestive tissues

S. Evrard, M. Koenig, C. Damge, Jacques Marescaux, M. Aprahamian

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199146
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

This report describes the discrepancy between pheophorbide A (PH-A) localization and photodynamically induced necrosis for the digestive tract. After an IV 9 mg/Kg^-1 sensitization, the dye was caught by the whole digestive tract and its inherent vessels, as shown by fluorescence microscopy. The dye fluorescence disappeared within 24 h from the stomach and the jejunum. It remained high in the pancreas, the portal vein, the bile duct, the arteries and the duodenal mucosae. A light dose, 660 nm, 100 J/cm^-2, 24 h after Ph-A sensitization, induced a necrosis of the duodenal mucosae. The pancreas and the hepatic pedicle were relatively unaffected by photodynamic therapy (PDT). The duodenal response to PDT results logically from its selective PH-A retention. But hepatic pedicule and pancreas immunities for PDT involve either protecting singlet oxygen scavengers or photosensitizer quenchers.

Citation Download Citation

S. Evrard, M. Koenig, C. Damge, Jacques Marescaux, and M. Aprahamian "Discrepancy between photodynamic injuries and pheophorbide A accumulation in digestive tissues", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199146

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