Determination of the optical coefficients of in vivo biological tissues by analysis of the coherent backscattering line shape

Miles H. Eddowes; Timothy N. Mills; David T. Delpy

doi:10.1117/12.200812

31 January 1995 Determination of the optical coefficients of in vivo biological tissues by analysis of the coherent backscattering line shape

Miles H. Eddowes, Timothy N. Mills, David T. Delpy

Author Affiliations +

Proceedings Volume 2326, Photon Transport in Highly Scattering Tissue; (1995) https://doi.org/10.1117/12.200812
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

Precise knowledge of the optical coefficients of a turbid biological medium is fundamental to the analysis of many optical therapeutic and diagnostic techniques that can now be found in medicine. It is unfortunate that the few successful techniques that have been developed for the measurement of absorption and reduced scattering coefficients have been limited to in vitro samples where the optical properties are almost certain to be significantly different to the corresponding in vivo state. The analysis of coherent backscattering peak lineshapes using an analytical solution derived from a scalar diffusion approximation has been recently reported but the results were inconsistent with the coefficients measured with an established method. The progress of this present study has resulted in the development of a Monte Carlo simulation of coherent backscatter from biological media which can cope with many of the practical limitations and theoretical simplifications that have been encountered (e.g., refractive index mismatches and a finite illumination spot size). Our initial results have highlighted the inaccuracies in the earlier study and suggest a novel strategy that may be used to determine the absorption and effective scattering coefficients of in vivo tissues with minimal invasion under clinical conditions.

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Miles H. Eddowes, Timothy N. Mills, and David T. Delpy "Determination of the optical coefficients of in vivo biological tissues by analysis of the coherent backscattering line shape", Proc. SPIE 2326, Photon Transport in Highly Scattering Tissue, (31 January 1995); https://doi.org/10.1117/12.200812

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