Treatment of hepatic tumors in rabbits using interstitial laser therapy: how complete is destruction?

Guy Marchal; Yicheng Ni; Frank van de Mierop; Jie Yu; Gregorius Lukito; Carine Petre; Paul Rutgeerts; Albert L. Baert

doi:10.1117/12.197568

23 December 1994 Treatment of hepatic tumors in rabbits using interstitial laser therapy: how complete is destruction?

Guy Marchal, Yicheng Ni, Frank van de Mierop, Jie Yu, Gregorius Lukito, Carine Petre, Paul Rutgeerts, Albert L. Baert

Proceedings Volume 2327, Medical Applications of Lasers II; (1994) https://doi.org/10.1117/12.197568
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

Interstitial laser thermotherapy (ILT) has recently been applied for palliative ablation of tumors in different organs. The present animal experiments were conducted to evaluate the feasibility of ILT for tumor eradication. Twenty two rabbits, 8 normal and 14 with implanted VX2 tumors in the liver, were treated with Neodymium-YAG laser using interstitial thermotherapy (ITT) fibers. Single and/or multiple laser applications were performed either percutaneously (normal livers) or under laparotomy (VX2 tumors) and monitored with CT and visual inspection respectively. Laser energy was 3 or 4.5 watts during 600 or 300 seconds application. After therapy, all lesions were followed up by contrast enhanced MRI. Finally the animals were sacrificed at various intervals and the livers were evaluated by macroscopy, microangiography, and microscopy. With no exception, some vessels with surrounding tumoral tissue remained undestroyed inside the macroscopic limits of the laser induced lesions. This caused tumor relapse during follow up. In the liver, vessels have a cooling effect and can shield adjacent tissues. Therefore there is a discrepancy between the macroscopic area of necrosis and the area of radical treatment.

Citation Download Citation

Guy Marchal, Yicheng Ni, Frank van de Mierop, Jie Yu, Gregorius Lukito, Carine Petre, Paul Rutgeerts, and Albert L. Baert "Treatment of hepatic tumors in rabbits using interstitial laser therapy: how complete is destruction?", Proc. SPIE 2327, Medical Applications of Lasers II, (23 December 1994); https://doi.org/10.1117/12.197568

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