Computational simulation of microfluidics, electrokinetics, and particle transport in biological MEMS devices

M. G. Giridharan; Soumya Krishnamoorthy; Anantha Krishnan

doi:10.1117/12.341184

10 March 1999 Computational simulation of microfluidics, electrokinetics, and particle transport in biological MEMS devices

M. G. Giridharan, Soumya Krishnamoorthy, Anantha Krishnan

Author Affiliations +

Proceedings Volume 3680, Design, Test, and Microfabrication of MEMS and MOEMS; (1999) https://doi.org/10.1117/12.341184
Event: Design, Test, and Microfabrication of MEMS/MOEMS, 1999, Paris, France

Abstract

Biological MEMS devices are being developed for applications in collection, monitoring, diagnostics and drug delivery. The objective of this work is to develop a simulation tool for the design, analysis and optimization of these devices. Simulations of biological MEMS devices are challenging due to the non-Newtonian behavior of biological fluids, coupling of flow with electric fields in electrophoretic separations, transport of non-homogeneous cellular structures and mixing between Newtonian and non-Newtonian fluids. This paper presents Computational Fluid Dynamic (CFD) simulations of biological fluid flow, mixing, electro-kinetics and transport of particles in microfluidic systems. A commercial CFD code, CFD-ACE+, that solves the full Navier-Stokes equations using a finite-volume approach has been adapted to perform these simulations of biological MEMS devices. Model predictions are validated through comparisons with experimental data.

Citation Download Citation

M. G. Giridharan, Soumya Krishnamoorthy, and Anantha Krishnan "Computational simulation of microfluidics, electrokinetics, and particle transport in biological MEMS devices", Proc. SPIE 3680, Design, Test, and Microfabrication of MEMS and MOEMS, (10 March 1999); https://doi.org/10.1117/12.341184

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