Absorption spectroscopic analysis of the pharmacokinetics of octa-alpha-butyloxy-zinc phthalocyanine in Lewis lung carcinoma-bearing mice

Cathrin Dressler; M. Samy Ismail; Simone Stroebele; Christian Nowak; Ralf Herter; Rainier G. Senz; Roland Hagemann; Peter Koeppe; Beate Roeder; Hans-Peter Berlien

doi:10.1117/12.203413

1 March 1995 Absorption spectroscopic analysis of the pharmacokinetics of octa-alpha-butyloxy-zinc phthalocyanine in Lewis lung carcinoma-bearing mice

Cathrin Dressler, M. Samy Ismail, Simone Stroebele, Christian Nowak, Ralf Herter, Rainier G. Senz, Roland Hagemann, Peter Koeppe, Beate Roeder, Hans-Peter Berlien

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Proceedings Volume 2371, 5th International Photodynamic Association Biennial Meeting; (1995) https://doi.org/10.1117/12.203413
Event: Fifth International Photodynamic Association Biennial Meeting, 1994, Amelia Island, FL, United States

Abstract

The phthalocyanines form a continuously growing family of potential photosensitizers. Their chemical and photophysical properties, and therefore their photodynamic activities, are influenced by the type of the central metal ion as well as the type and localization of substituents. Plasma and tissue distribution kinetics are also dependent on the chemical features of a dye molecule. We therefore investigated the pharmacokinetics of newly synthesized octa-(alpha) -butyloxy-zincphthalocyanine (8-(alpha) -bo-ZnPc) on the Lewis lung carcinoma in order to evaluate the application possibilities of this compound in experimental PDT treatments. The zinc complex was chosen on the basis of the known effect of this metal on the photochemical and photophysical properties of phthalocyanines. The pharmacokinetics of octa-(alpha) -butyloxy-zincphthalocyanine were studied on the Lewis lung carcinoma by absorption spectroscopy in mice. Afterwards a regression analysis was performed using the absorption spectroscopic data.

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Cathrin Dressler, M. Samy Ismail, Simone Stroebele, Christian Nowak, Ralf Herter, Rainier G. Senz, Roland Hagemann, Peter Koeppe, Beate Roeder, and Hans-Peter Berlien "Absorption spectroscopic analysis of the pharmacokinetics of octa-alpha-butyloxy-zinc phthalocyanine in Lewis lung carcinoma-bearing mice", Proc. SPIE 2371, 5th International Photodynamic Association Biennial Meeting, (1 March 1995); https://doi.org/10.1117/12.203413

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