In-vivo cancer diagnosis of the esophagus using laser-induced fluorescence

Tuan Vo-Dinh; Masoud Panjehpour; Bergein F. Overholt M.D.; Paul F. Buckley II; Donna H. Edwards

doi:10.1117/12.206821

12 April 1995 In-vivo cancer diagnosis of the esophagus using laser-induced fluorescence

Tuan Vo-Dinh, Masoud Panjehpour, Bergein F. Overholt M.D., Paul F. Buckley II, Donna H. Edwards

Proceedings Volume 2387, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II; (1995) https://doi.org/10.1117/12.206821
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

Laser-induced fluorescence (LIF) was used for direct in-vivo cancer diagnosis of the esophagus without requiring biopsy. The methodology was applied to differentiate normal and malignant tumors of the esophagus. Endogenous fluorescence of normal and malignant tissues were measured directly using a fiberoptic probe inserted through an endoscope. The measurements were performed in vivo during routine endoscopy. Detection of the fluorescence signal from the tissue was performed using laser excitation. The results of this LIF approach were compared with histopathology results of the biopsy samples and indicated excellent agreement in the classification of normal and malignant tumors for the samples investigated. The LIF procedure could lead to the development of a rapid and cost-effective technique for cancer diagnosis.

Citation Download Citation

Tuan Vo-Dinh, Masoud Panjehpour, Bergein F. Overholt M.D., Paul F. Buckley II, and Donna H. Edwards "In-vivo cancer diagnosis of the esophagus using laser-induced fluorescence", Proc. SPIE 2387, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases II, (12 April 1995); https://doi.org/10.1117/12.206821

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